Overview

  • Product name

    Anti-PTPN13/FAP-1 antibody
  • Description

    Rabbit polyclonal to PTPN13/FAP-1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human PTPN13/FAP-1 (internal sequence). NP_542414.
    Database link: Q12923

  • Positive control

    • Human cervical cancer and thyroid cancer tissues.
  • General notes

     This product was previously labelled as PTPN13

     

Properties

Applications

Our Abpromise guarantee covers the use of ab198882 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100.

Target

  • Relevance

    PTPN13 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as I-kappa-B-alpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway.
  • Cellular localization

    Cytoplasmic
  • Database links

  • Alternative names

    • APO1/CD95 (Fas) associated phosphatase antibody
    • DKFZp686J1497 antibody
    • FAP 1 antibody
    • FAP1 antibody
    • Fas associated phosphatase 1 antibody
    • Fas associated protein tyrosine phosphatase 1 antibody
    • HGNC:9646 antibody
    • hPTPE1 antibody
    • Phosphatase rip antibody
    • PNP 1 antibody
    • PNP1 antibody
    • Protein tyrosine phosphatase 1 Fas associated antibody
    • protein tyrosine phosphatase 1E antibody
    • Protein tyrosine phosphatase non receptor type 13 antibody
    • Protein tyrosine phosphatase nonreceptor type 13 antibody
    • Protein tyrosine phosphatase PTPL1 antibody
    • protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) antibody
    • PTP BAS antibody
    • PTP BL antibody
    • PTP E1 antibody
    • PTP1E antibody
    • PTPL 1 antibody
    • PTPL1 antibody
    • PTPLE antibody
    • PTPN 13 antibody
    • PTPN13 antibody
    • Tyrosine protein phosphatase non receptor type 13 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue labeling PTPN13/FAP-1 with ab198882 at 1/30 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling PTPN13/FAP-1 with ab198882 at 1/30 dilution.

References

This product has been referenced in:

  • Huang W  et al. Inhibition of Fas associated phosphatase 1 (Fap1) facilitates apoptosis of colon cancer stem cells and enhances the effects of oxaliplatin. Oncotarget 9:25891-25902 (2018). Read more (PubMed: 29899829) »
  • Wang Y  et al. Protein tyrosine phosphatase L1 inhibits high-grade serous ovarian carcinoma progression by targeting I?Ba. Onco Targets Ther 11:7603-7612 (2018). Read more (PubMed: 30464509) »
See all 3 Publications for this product

Customer reviews and Q&As

Application
Western blot
Sample
Human Cell lysate - whole cell (Primary airway cells)
Gel Running Conditions
Reduced Denaturing
Loading amount
20 µg
Specification
Primary airway cells
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: RT°C

Abcam user community

Verified customer

Submitted Aug 02 2019

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