Key features and details
- Goat polyclonal to PTPN22
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 98% Tris buffered saline
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab118430 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 3.75 - 7.5 µg/ml.|
FunctionSeems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases.
Tissue specificityPredominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
Contains 1 tyrosine-protein phosphatase domain.
modificationsPhosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases.
- Information by UniProt
- Hematopoietic cell protein tyrosine phosphatase 70Z PEP antibody
- Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP antibody
- Lymphoid phosphatase antibody
ab118430 at 7.5ug/ml staining PTPN22 in Formalin-fixed, Paraffin-embedded Human adrenal tissue by Immunohistochemistry.
ab118430 at 7.5ug/ml staining PTPN22 in Formalin-fixed, Paraffin-embedded Human thyroid tissue by Immunohistochemistry.
ab118430 at 7.5ug/ml staining PTPN22 in Formalin-fixed, Paraffin-embedded Human small intestine tissue by Immunohistochemistry.
ab118430 has not yet been referenced specifically in any publications.