The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/50 - 1/100 (Diluent: Renoir Red). Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.
Belongs to the ETS family. Contains 1 ETS DNA-binding domain.
Martinez A et al. Expression of the interferon regulatory factor 8/ICSBP-1 in human reactive lymphoid tissues and B-cell lymphomas: a novel germinal center marker. Am J Surg Pathol32:1190-200 (2008).
Read more (PubMed: 18580679) »
Cattoretti G et al. Stages of germinal center transit are defined by B cell transcription factor coexpression and relative abundance. J Immunol177:6930-9 (2006).
Read more (PubMed: 17082608) »