PugNAc, hexosaminidase A and B inhibitor (ab144670)

Overview

  • Product name

    PugNAc, hexosaminidase A and B inhibitor
  • Description

    Potent O-GlcNAcase, hexosaminidase A and B inhibitor
  • Biological description

    Potent O-GlcNAcase, hexosaminidase A and B inhibitor (IC50 values are 6, 25, 35 and 46 nM for β-hexosaminidase, HeX A/B, hOGA and OGA respectively). Decreases GLUT4 translocation and insulin-stimulated 2-deoxyglucose uptake in adipocytes. Shows antiapoptotic effects.

  • CAS Number

    132489-69-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [(Z)-[(3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-ylidene]amino] N-phenylcarbamate
  • Molecular weight

    353.33
  • Molecular formula

    C15H19N3O7
  • PubChem identifier

    9576811
  • Storage instructions

    Store at -20°C. Store In the Dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)N[C@@H]\1[C@H]([C@@H]([C@H](O/C1=N\OC(=O)NC2=CC=CC=C2)CO)O)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Johnson B  et al. Implications of the O-GlcNAc modification in the regulation of nuclear apoptosis in T cells. Biochim Biophys Acta 1840:191-8 (2014). Read more (PubMed: 24035784) »
  • Kanwal S  et al. O-GlcNAcylation-inducing treatments inhibit estrogen receptor a expression and confer resistance to 4-OH-tamoxifen in human breast cancer-derived MCF-7 cells. PLoS One 8:e69150 (2013). Read more (PubMed: 23935944) »
  • Arias EB  et al. Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle. Diabetes 53:921-30 (2004). Read more (PubMed: 15047606) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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