Overview

  • Product name

    Anti-Puma gamma/GPR109A antibody
    See all Puma gamma/GPR109A primary antibodies
  • Description

    Rabbit polyclonal to Puma gamma/GPR109A
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human Puma gamma/GPR109A (internal sequence). The exact sequence is proprietary. NCBI Accession No. NP_808219.
    Database link: Q8TDS4

  • Positive control

    • Human gastric cancer and thyroid cancer tissues.
  • General notes

     This product was previously labelled as Puma gamma

     

Properties

Applications

Our Abpromise guarantee covers the use of ab198693 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/40 - 1/300. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
  • Tissue specificity

    Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Developmental stage

    Expression in neutrophils occurs in the late terminal differentiation phase.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • G protein coupled receptor 109A antibody
    • G protein coupled receptor HM74a antibody
    • G protein coupled receptor Hm74b antibody
    • G-protein coupled receptor 109A antibody
    • G-protein coupled receptor HM74A antibody
    • G109A_HUMAN antibody
    • GPR 109A antibody
    • Gpr109a antibody
    • GPR109A protein antibody
    • HCA2 antibody
    • HCAR2 antibody
    • HM 74 antibody
    • HM 74a antibody
    • HM 74b antibody
    • Hm74 antibody
    • HM74a antibody
    • HM74b antibody
    • hydroxycarboxylic acid receptor 2 antibody
    • Interferon gamma inducible gene Puma g antibody
    • Niacin receptor 1 antibody
    • NIACR1 antibody
    • Nicotinic acid receptor 1 antibody
    • Nicotinic acid receptor antibody
    • Protein upregulated in macrophages by IFNG, mouse, homolog of antibody
    • Puma g antibody
    • Pumag antibody
    • rHM74b antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue labeling Puma gamma/GPR109A using ab198693 at a 1/40 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling Puma gamma/GPR109A using ab198693 at a 1/40 dilution.

References

This product has been referenced in:

  • Boccella S  et al. Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain. FASEB J 33:1062-1073 (2019). Read more (PubMed: 30085883) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab198693.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up