• Product name

    Anti-Puma gamma/GPR109A antibody
    See all Puma gamma/GPR109A primary antibodies
  • Description

    Rabbit polyclonal to Puma gamma/GPR109A
  • Host species

  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human Puma gamma/GPR109A (internal sequence). The exact sequence is proprietary. NCBI Accession No. NP_808219.
    Database link: Q8TDS4

  • Positive control

    • Human gastric cancer and thyroid cancer tissues.
  • General notes

     This product was previously labelled as Puma gamma




Our Abpromise guarantee covers the use of ab198693 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/40 - 1/300. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • Function

    Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
  • Tissue specificity

    Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Developmental stage

    Expression in neutrophils occurs in the late terminal differentiation phase.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • G protein coupled receptor 109A antibody
    • G protein coupled receptor HM74a antibody
    • G protein coupled receptor Hm74b antibody
    • G-protein coupled receptor 109A antibody
    • G-protein coupled receptor HM74A antibody
    • G109A_HUMAN antibody
    • GPR 109A antibody
    • Gpr109a antibody
    • GPR109A protein antibody
    • HCA2 antibody
    • HCAR2 antibody
    • HM 74 antibody
    • HM 74a antibody
    • HM 74b antibody
    • Hm74 antibody
    • HM74a antibody
    • HM74b antibody
    • hydroxycarboxylic acid receptor 2 antibody
    • Interferon gamma inducible gene Puma g antibody
    • Niacin receptor 1 antibody
    • NIACR1 antibody
    • Nicotinic acid receptor 1 antibody
    • Nicotinic acid receptor antibody
    • Protein upregulated in macrophages by IFNG, mouse, homolog of antibody
    • Puma g antibody
    • Pumag antibody
    • rHM74b antibody
    see all


  • Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue labeling Puma gamma/GPR109A using ab198693 at a 1/40 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling Puma gamma/GPR109A using ab198693 at a 1/40 dilution.


This product has been referenced in:

  • Boccella S  et al. Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain. FASEB J 33:1062-1073 (2019). Read more (PubMed: 30085883) »
See 1 Publication for this product

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