Key features and details
- Smoothened receptor agonist
- CAS Number: 483367-10-8
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Product namePurmorphamine, Smoothened receptor agonist
DescriptionSmoothened receptor agonist
Smoothened (Smo) receptor agonist (EC50 ~ 1 μM). Induces osteogenesis in mouse mesenchymal progenitor cells . When combined with BMP-4, can transdifferentiate pre-adipocytes and myoblasts into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Research Area
- Alzheimer's Disease
- Signal transduction
- Hedgehog signaling
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120933 has been referenced in 5 publications.
- Senatore E et al. The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation. EMBO J 40:e106503 (2021). PubMed: 33934390
- Malave L et al. Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson's disease and L-Dopa induced dyskinesia. Commun Biol 4:1071 (2021). PubMed: 34552196
- Park SR et al. Sonic Hedgehog, a Novel Endogenous Damage Signal, Activates Multiple Beneficial Functions of Human Endometrial Stem Cells. Mol Ther 28:452-465 (2020). PubMed: 31866117
- Kozielewicz P et al. Structural insight into small molecule action on Frizzleds. Nat Commun 11:414 (2020). PubMed: 31964872
- Cho A et al. An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2. Mol Ther 27:1286-1298 (2019). PubMed: 31080015