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    puromycin-dihydrochloride-protein-biosynthesis-inhibitor-ab141453.pdf

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Cell Biology Apoptosis Nucleus Other
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Puromycin dihydrochloride, Protein biosynthesis inhibitor (ab141453)

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Key features and details

  • Aminonuclease antibiotic agent. Protein biosynthesis inhibitor.
  • CAS Number: 58-58-2
  • Purity: > 98%
  • Soluble in water to 75 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    Puromycin dihydrochloride, Protein biosynthesis inhibitor
  • Description

    Aminonuclease antibiotic agent. Protein biosynthesis inhibitor.
  • Biological description

    Aminonuclease antibiotic agent. Protein biosynthesis inhibitor. Induces cell cycle arrest in G2/M phase and apoptosis. Inhibits transport of proteins into mitochondria. Inhibits translation in vivo.
  • Purity

    > 98%
  • CAS Number

    58-58-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S)-2-Amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide dihydrochloride
  • Molecular weight

    544.43
  • Molecular formula

    C22H29N7O5.2HCl
  • PubChem identifier

    443311
  • Storage instructions

    Store at -20°C (desiccating conditions).
  • Solubility overview

    Soluble in water to 75 mM
  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O.Cl.Cl
  • Source

    Synthetic

  • Research areas

    • Cell Biology
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    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

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    References (1)

    Publishing research using ab141453? Please let us know so that we can cite the reference in this datasheet.

    ab141453 has been referenced in 1 publication.

    • Gao Q  et al. SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC. Cell Death Differ N/A:N/A (2019). PubMed: 31367013

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