Puromycin dihydrochloride, Protein biosynthesis inhibitor (ab141453)
Key features and details
- Aminonuclease antibiotic agent. Protein biosynthesis inhibitor.
- CAS Number: 58-58-2
- Purity: > 98%
- Soluble in water to 75 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Puromycin dihydrochloride, Protein biosynthesis inhibitor -
Description
Aminonuclease antibiotic agent. Protein biosynthesis inhibitor. -
Biological description
Aminonuclease antibiotic agent. Protein biosynthesis inhibitor. Induces cell cycle arrest in G2/M phase and apoptosis. Inhibits transport of proteins into mitochondria. Inhibits translation in vivo. -
Purity
> 98% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called 1860 Puromycin Dihydrochloride. 1860-250 is the same size as the 250 mg size of ab141453.
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CAS Number
58-58-2 -
Chemical structure
Properties
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Chemical name
(2S)-2-Amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide dihydrochloride -
Molecular weight
544.43 -
Molecular formula
C22H29N7O5.2HCl -
PubChem identifier
443311 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Soluble in water to 75 mM -
Handling
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O.Cl.Cl -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Puromycin dihydrochloride, Protein biosynthesis inhibitor (ab141453)2D chemical structure image of ab141453, Puromycin dihydrochloride, Protein biosynthesis inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab141453 has been referenced in 2 publications.
- Hu J et al. Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation. Theranostics 11:805-823 (2021). PubMed: 33391506
- Gao Q et al. SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC. Cell Death Differ N/A:N/A (2019). PubMed: 31367013