Puromycin dihydrochloride, Protein biosynthesis inhibitor (ab141453)
- Datasheet
- References (1)
Overview
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Product name
Puromycin dihydrochloride, Protein biosynthesis inhibitor -
Description
Aminonuclease antibiotic agent. Protein biosynthesis inhibitor. -
Biological description
Aminonuclease antibiotic agent. Protein biosynthesis inhibitor. Induces cell cycle arrest in G2/M phase and apoptosis. Inhibits transport of proteins into mitochondria. Inhibits translation in vivo. -
Purity
> 98% -
CAS Number
58-58-2 -
Chemical structure
Properties
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Chemical name
(2S)-2-Amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide dihydrochloride -
Molecular weight
544.43 -
Molecular formula
C22H29N7O5.2HCl -
PubChem identifier
443311 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Soluble in water to 75 mM -
Handling
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O.Cl.Cl -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Tabuchi I Next-generation protein-handling method: puromycin analogue technology. Biochem Biophys Res Commun 305:1-5 (2003). Read more (PubMed: 12732187) »
- Constam DB et al. Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization. J Biol Chem 270:26931-9 (1995). Read more (PubMed: 7592939) »
