Overview

  • Product name

    Anti-PVRL1/NECTIN1 antibody [R1.302]
    See all PVRL1/NECTIN1 primary antibodies
  • Description

    Mouse monoclonal [R1.302] to PVRL1/NECTIN1
  • Host species

    Mouse
  • Tested applications

    Suitable for: Flow Cytmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Tissue, cells or virus corresponding to Human PVRL1/NECTIN1. (NIH/3T3 cells transfected with human PVRL1/NECTIN1).

  • Positive control

    • Flow Cytometry: Human peripheral blood.
  • General notes

     This product was previously labelled as PVRL1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab234128 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.

Target

  • Function

    Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4.
  • Involvement in disease

    Defects in PVRL1 are the cause of ectodermal dysplasia Margarita Island type (EDMI) [MIM:225060]; also known as Zlotogora-Ogur syndrome, cleft lip/palate-ectodermal dysplasia syndrome (CLPED1) or ectodermal dysplasia 4. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDMI is an autosomal recessive syndrome characterized by the association of cleft lip/palate, ectodermal dysplasia (sparse short and dry scalp hair, sparse eyebrows and eyelashes), and partial syndactyly of the fingers and/or toes. Two thirds of the patients do not manifest oral cleft but present with abnormal teeth and nails.
    Defects in PVRL1 are the cause of non-syndromic orofacial cleft type 7 (OFC7) [MIM:225060]. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
  • Sequence similarities

    Belongs to the nectin family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD111 antibody
    • CD111 antigen antibody
    • CLPED1 antibody
    • ectodermal dysplasia 4 (Margarita Island type) antibody
    • ED4 antibody
    • Herpes virus entry mediator C antibody
    • Herpesvirus entry mediator C antibody
    • Herpesvirus Ig like receptor antibody
    • Herpesvirus Ig-like receptor antibody
    • HIgR antibody
    • HveC antibody
    • MGC142031 antibody
    • Nectin 1 antibody
    • Nectin-1 antibody
    • OFC7 antibody
    • OROFACIAL CLEFT 7 antibody
    • OTTHUMP00000232093 antibody
    • OTTHUMP00000232094 antibody
    • OTTHUMP00000232095 antibody
    • Poliovirus receptor related protein 1 antibody
    • poliovirus receptor-like 1 antibody
    • Poliovirus receptor-related protein 1 antibody
    • PRR antibody
    • PRR1 antibody
    • PVRL 1 antibody
    • PVRL1 antibody
    • PVRL1_HUMAN antibody
    • PVRR antibody
    • PVRR1 antibody
    • SK-12 antibody
    see all

Images

  • Flow cytometric analysis of human peripheral blood labeling PVRL1/NECTIN1 with ab234128, followed by Goat-anti Mouse APC.

References

ab234128 has not yet been referenced specifically in any publications.

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