Overview

  • Product name

    PX 12, Thioredoxin-1 inhibitor
  • Description

    Irreversible, competitive Thioredoxin-1 inhibitor
  • Biological description

    Irreversible, competitive Thioredoxin-1 inhibitor (Ki = 30.8 μM). Attenuates HIF-1α, VEGF and iNOS expression (IC50 values are 7.2, 10.4 and 18.1 μM, respectively). Inhibits tubulin and decreases tumor blood vessel density. Shows antitumor effects in vivo.
  • Purity

    > 98%
  • CAS Number

    141400-58-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(Butan-2-yldisulfanyl)-1H-imidazole
  • Molecular weight

    188.31
  • Molecular formula

    C7H12N2S2
  • PubChem identifier

    219104
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC(C)SSC1=NC=CN1
  • Source

    Synthetic

References

This product has been referenced in:

  • Jordan BF  et al. The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging. Clin Cancer Res 11:529-36 (2005). Read more (PubMed: 15701837) »
  • Welsh SJ  et al. The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation. Mol Cancer Ther 2:235-43 (2003). Read more (PubMed: 12657718) »
  • Kirkpatrick DL  et al. Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides. Biochem Pharmacol 55:987-94 (1998). Read more (PubMed: 9605422) »

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