Overview

  • Product name

  • Description

    Rabbit polyclonal to PXR
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Rat, Human
  • Immunogen

    Synthetic peptide within Human PXR aa 80-130 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: O75469

  • Positive control

    • Mouse small intestine tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab217375 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/300.

Target

  • Function

    Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
  • Tissue specificity

    Expressed in liver, colon and small intestine.
  • Sequence similarities

    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • BXR antibody
    • Nr1i2 antibody
    • NR1I2_HUMAN antibody
    • Nuclear receptor subfamily 1 group I member 2 antibody
    • ONR 1 antibody
    • ONR1 antibody
    • Orphan nuclear receptor PAR 1 antibody
    • Orphan nuclear receptor PAR1 antibody
    • Orphan nuclear receptor PXR antibody
    • OTTHUMP00000215173 antibody
    • OTTHUMP00000215174 antibody
    • OTTHUMP00000215175 antibody
    • PAR 1 antibody
    • PAR 2 antibody
    • PAR antibody
    • PAR q antibody
    • PAR1 antibody
    • PAR2 antibody
    • PARq antibody
    • pregnane X nuclear receptor variant 2 antibody
    • Pregnane X receptor antibody
    • PRR antibody
    • PXR antibody
    • SAR antibody
    • Steroid and xenobiotic receptor antibody
    • SXR antibody
    see all

Images

  • Anti-PXR antibody (ab217375) at 1/300 dilution + Liver lysates

    Secondary
    Conjugated secondary antibody at 1/10000 dilution
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of Mouse small intestine tissue labeling PXR with ab217375 at a 1/400 dilution, followed by a conjugated secondary and DAB staining.

References

ab217375 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab217375.
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