Overview

  • Product name

  • Description

    Rabbit polyclonal to PYCR1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 290-319 of Human PYCR1, conjugated to KLH.

  • Positive control

    • HepG2 cell line lysates (WB), colon carcinoma tissue (IHC-P)

Properties

Applications

Our Abpromise guarantee covers the use of ab103314 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 33 kDa.
IHC-P 1/50 - 1/100.

Target

  • Relevance

    PYCR1 is an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. It forms a homopolymer and localizes to the mitochondrion.
  • Cellular localization

    Mitochondrial
  • Database links

  • Alternative names

    • P5C antibody
    • P5C reductase 1 antibody
    • P5C reductase antibody
    • P5CR 1 antibody
    • P5CR antibody
    • PIG45 antibody
    • PP222 antibody
    • Proliferation inducing protein 45 antibody
    • PYCR 1 antibody
    • PYCR antibody
    • Pyrroline 5 carboxylate reductase 1 antibody
    • Pyrroline 5 carboxylate reductase 1 mitochondrial antibody
    see all

Images

  • Anti-PYCR1 antibody (ab103314) at 1/100 dilution + HepG2 cell line lysate at 35 µg

    Predicted band size: 33 kDa

  • Immunohistochemical analysis of PYCR1 in formalin fixed and paraffin embedded Human colon carcinoma tissue, using ab103314 at a 1/50 dilution followed by peroxidase conjugation of the secondary antibody and DAB staining.

References

This product has been referenced in:

  • Wang D  et al. PYCR1 promotes the progression of non-small-cell lung cancer under the negative regulation of miR-488. Biomed Pharmacother 111:588-595 (2019). Read more (PubMed: 30605882) »
See 1 Publication for this product

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