Overview

  • Product name
    PYR-41, Ubiquitin-activating enzyme (E1) inhibitor
  • Description
    Ubiquitin-activating enzyme (E1) inhibitor
  • Biological description
    Ubiquitin-activating enzyme (E1) inhibitor (IC50 = 5 µM). Inhibits ubiquitination and proteasomal degradation. Additionally increases sumoylation of proteins and induces p53-mediated apoptosis.
  • Purity
    > 98%
  • CAS Number
    418805-02-4
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Ungermannova D  et al. Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. J Biomol Screen 17:421-34 (2012). Read more (PubMed: 22274912) »
  • Guan H & Ricciardi RP Transformation by E1A oncoprotein involves ubiquitin-mediated proteolysis of the neuronal and tumor repressor REST in the nucleus. J Virol 86:5594-602 (2012). Read more (PubMed: 22419809) »
  • Yang Y  et al. Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res 67:9472-81 (2007). Read more (PubMed: 17909057) »

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