Pyridoxal- 5'-phosphate monohydrate, Vitamin B6 metabolite (ab146228)

Overview

  • Product name

    Pyridoxal- 5'-phosphate monohydrate, Vitamin B6 metabolite
  • Description

    Vitamin B6 metabolite.
  • Alternative names

    • 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde
    • Codecarboxylase
    • P5P
    • PLP
    • Pyridoxal 5-phosphate
    see all
  • Biological description

    Vitamin B6 metabolite that acts as a coenzyme in transamination reactions by forming a Schiff-base linkage with lysine groups on aminotransferase. Also serves as a coenzyme in some decarboxylation and deamination reactions. Can modify lysyl and valyl residues in proteins. Has the ability to inhibit purinergic receptors and intracellular influx of Ca2+

  • Purity

    > 98%
  • CAS Number

    41468-25-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde monohydrate
  • Molecular weight

    265.16
  • Molecular formula

    C8H10NO6P.H2O
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Lowther J  et al. Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation. Mol Biosyst 6:1682-93 (2010). Read more (PubMed: 20445930) »
  • Neuwirth M  et al. X-ray crystal structure of Saccharomyces cerevisiae Pdx1 provides insights into the oligomeric nature of PLP synthases. FEBS Lett 583:2179-86 (2009). Read more (PubMed: 19523954) »
  • Simon ES & Allison J Determination of pyridoxal-5'-phosphate (PLP)-bonding sites in proteins: a peptide mass fingerprinting approach based on diagnostic tandem mass spectral features of PLP-modified peptides. Rapid Commun Mass Spectrom 23:3401-8 (2009). Read more (PubMed: 19810014) »
  • Kim DW  et al. Inactivation of brain myo-inositol monophosphate phosphatase by pyridoxal-5'-phosphate. J Biochem Mol Biol 38:58-64 (2005). Read more (PubMed: 15715947) »
  • Kandzari DE  et al. Reduction of myocardial ischemic injury following coronary intervention (the MC-1 to Eliminate Necrosis and Damage trial). Am J Cardiol 92:660-4 (2003). Read more (PubMed: 12972102) »

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