Pyridoxal isonicotinoyl hydrazone (PIH), hydrazone iron chelator (ab145871)

Overview

  • Product name

    Pyridoxal isonicotinoyl hydrazone (PIH), hydrazone iron chelator
  • Description

    Cell-permeable non-toxic hydrazone iron chelator
  • Alternative names

    • PIH
  • Biological description

    Cell-permeable non-toxic hydrazone iron chelator. Prevents iron-mediated oxyradical formation and minimizes tissue damage. Anticancer and apoptotic agent. Active in vitro.

    See similar compounds
  • Purity

    > 99%
  • CAS Number

    737-86-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[[3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl]methylene]hydrazide 4-pyridinecarboxylic acid
  • Molecular weight

    286.29
  • Molecular formula

    C14H14N4O3
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=NC=C(C(=CNNC(=O)C2=CC=NC=C2)C1=O)CO
  • Source

    Synthetic

References

This product has been referenced in:

  • Buss JL  et al. Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating properties. Biochem Pharmacol 65:161-72 (2003). Read more (PubMed: 12504792) »
  • Santos NC  et al. The iron chelator pyridoxal isonicotinoyl hydrazone inhibits mitochondrial lipid peroxidation induced by Fe(II)-citrate. Eur J Pharmacol 428:37-44 (2001). Read more (PubMed: 11779035) »
  • Richardson DR & Milnes K The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone. Blood 89:3025-38 (1997). Read more (PubMed: 9108424) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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