Pyrimethamine, dihydrofolate reductase inhibitor (ab143106)

Overview

  • Product name

    Pyrimethamine, dihydrofolate reductase inhibitor
  • Description

    Competitive dihydrofolate reductase inhibitor. Potent MATE transporter inhibitor.
  • Biological description

    Competitive dihydrofolate reductase inhibitor. Potent MATE transporter inhibitor (Ki values are 46 and 77 nM for hMATE-2 and hMATE-1 respectively). Inhibits SOD1. Shows antiprotazoal effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    58-14-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Rochford R  et al. Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity. Proc Natl Acad Sci U S A 110:17486-91 (2013). Read more (PubMed: 24101478) »
  • Ito S  et al. Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine. J Pharmacol Exp Ther 333:341-50 (2010). Read more (PubMed: 20065018) »
  • Zimmerman J  et al. Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimethoprim and pyrimethamine. Am J Clin Nutr 46:518-22 (1987). Read more (PubMed: 3630970) »

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