Overview

  • Product name

    Pyrimidyn-7™, dynamin inhibitor
  • Description

    Novel, potent dual action dynamin inhibitor
  • Biological description

    Novel, potent dual action dynamin inhibitor (IC50 values are 1.1 and 1.8 µM at dynamin I and II respectively). Only inhibitor to target two distinct domains of dynamin.
    Competitively inhibits both GTP and phospholipid binding. Reversibly inhibits clathrin mediated endocytosis (CME) and synaptic vesicle endocytosis (SVE) in nerve terminals.
  • Purity

    > 97%
  • General notes

    Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Pyrimidyn™ is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd
  • CAS Number

    1440126-94-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N2-[2-(Dimethylamino)ethyl]-N4-dodecyl-6-methyl-2,4-pyrimidinediamine
  • Molecular weight

    363.59
  • Molecular formula

    C21H41N5
  • Storage instructions

    Store at -20°C (desiccating conditions).
  • Solubility overview

    Supplied in DMSO (50 mM)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C)CCNc1nc(C)cc(NCCCCCCCCCCCC)n1
  • Source

    Synthetic

References

This product has been referenced in:

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