Pyrintegrin, enhances hESC survival (ab142093)

Overview

  • Product name

    Pyrintegrin, enhances hESC survival
  • Description

    Pyrimidine compound that enhances hESC survival
  • Alternative names

    • Ptn
  • Biological description

    Pyrimidine compound that enhances hESC survival. Substantially reduces trypsinization-induced apoptosis while maintaining cells’ self-renewal ability and pluripotency of expanded cultures. Induces activation of β1 integrin and multiple growth factor receptors, including FGFR1, IGFR1, EGFR1, and ErbB2. Active in vitro.
  • Purity

    > 95%
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(Cyclopropylmethyl)-4-(4-(6-hydroxy-3,4-dihydroquinolin-1-(2H)-yl)pyrimidin-2-ylamino)benzenesulfonamide
  • Molecular weight

    451.54
  • Molecular formula

    C23H25N5O3S
  • PubChem identifier

    46223724
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CC2=C(C=CC(=C2)O)N(C1)C3=NC(=NC=C3)NC4=CC=C(C=C4)S(=O)(=O)NCC5CC5
  • Source

    Synthetic

References

This product has been referenced in:

  • Xu Y  et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci U S A 107:8129-34 (2010). Read more (PubMed: 20406903) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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