Pyronaridine tetraphosphate, Antimalarial agent (ab142696)

Overview

  • Product name

    Pyronaridine tetraphosphate, Antimalarial agent
  • Description

    Antimalarial agent
  • Biological description

    Antimalarial agent found to enhance antitumor activity of doxorubicin against multidrug-resistant cancers. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    76748-86-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[(7-Chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one tetraphosphoric acid
  • Molecular weight

    910.03
  • Molecular formula

    C29H32ClN5O2.4H3P04
  • PubChem identifier

    5488630
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC=C2C(=C(C3=C(N2)C=C(C=C3)Cl)N=C4C=C(C(=O)C(=C4)CN5CCCC5)CN6CCCC6)N1.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Qi J  et al. Pyronaridine, a novel modulator of P-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo. Biochem Biophys Res Commun 319:1124-31 (2004). Read more (PubMed: 15194484) »
  • Chen C & Zheng X Development of the new antimalarial drug pyronaridine: a review. Biomed Environ Sci 5:149-60 (1992). Read more (PubMed: 1642789) »
  • Chang C  et al. Studies on a new antimalarial compound: pyronaridine. Trans R Soc Trop Med Hyg 86:7-10 (0). Read more (PubMed: 1566313) »

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