Pyruvate dehydrogenase (PDH) Enzyme Activity Microplate Assay Kit (ab109902)

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ab109902 has been referenced in 39 publications.

  • Scheffler K  et al. 8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis. DNA Repair (Amst) 61:56-62 (2018). PubMed: 29207315
  • Corbet C  et al. Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects. Nat Commun 9:1208 (2018). PubMed: 29572438
  • Ma WQ  et al. Ne-carboxymethyl-lysine promotes calcium deposition in VSMCs via intracellular oxidative stress-induced PDK4 activation and alters glucose metabolism. Oncotarget 8:112841-112854 (2017). Human . PubMed: 29348870
  • Nguyen QL  et al. Platelets from pulmonary hypertension patients show increased mitochondrial reserve capacity. JCI Insight 2:e91415 (2017). PubMed: 28289721
  • Subramani K  et al. Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock. Sci Rep 7:2671 (2017). PubMed: 28572638
  • Lilla N  et al. First Description of Reduced Pyruvate Dehydrogenase Enzyme Activity Following Subarachnoid Hemorrhage (SAH). Front Neurosci 11:37 (2017). PubMed: 28261039
  • Guglielmetti C  et al. In vivo metabolic imaging of Traumatic Brain Injury. Sci Rep 7:17525 (2017). PubMed: 29235509
  • Guglielmetti C  et al. Hyperpolarized13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proc Natl Acad Sci U S A 114:E6982-E6991 (2017). PubMed: 28760957
  • Wan X  et al. Orexin A affects HepG2 human hepatocellular carcinoma cells glucose metabolism via HIF-1a-dependent and -independent mechanism. PLoS One 12:e0184213 (2017). PubMed: 28886081
  • Liu W  et al. Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling. Nat Commun 8:494 (2017). PubMed: 28887535
  • Blanquer-Rosselló MDM  et al. Leptin regulates energy metabolism in MCF-7 breast cancer cells. Int J Biochem Cell Biol 72:18-26 (2016). Functional Studies ; Human . PubMed: 26772821
  • Zhang Y  et al. Induction of Posttranslational Modifications of Mitochondrial Proteins by ATP Contributes to Negative Regulation of Mitochondrial Function. PLoS One 11:e0150454 (2016). Functional Studies ; Mouse . PubMed: 26930489
  • Golias T  et al. Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours. Sci Rep 6:31146 (2016). PubMed: 27498883
  • Bround MJ  et al. Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase. J Biol Chem 291:23490-23505 (2016). PubMed: 27621312
  • Sun J  et al. Induction of triglyceride accumulation and mitochondrial maintenance in muscle cells by lactate. Sci Rep 6:33732 (2016). Functional Studies . PubMed: 27645401
  • Shanmughapriya S  et al. Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU. Sci Signal 8:ra23 (2015). Functional Studies . PubMed: 25737585
  • Prabhu A  et al. Ras-mediated modulation of pyruvate dehydrogenase activity regulates mitochondrial reserve capacity and contributes to glioblastoma tumorigenesis. Neuro Oncol 17:1220-30 (2015). PubMed: 25712957
  • Aoi W  et al. The effect of Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon) and its derived ingredient methylthioacetic acid on energy metabolism during aerobic exercise. Springerplus 4:377 (2015). PubMed: 26217554
  • Findlay JA  et al. BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid. Front Cell Neurosci 9:382 (2015). PubMed: 26483636
  • Luongo TS  et al. The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition. Cell Rep 12:23-34 (2015). Functional Studies ; Mouse . PubMed: 26119731
  • Prabhu A  et al. Cysteine catabolism: a novel metabolic pathway contributing to glioblastoma growth. Cancer Res 74:787-96 (2014). Functional Studies ; Human . PubMed: 24351290
  • Yamane K  et al. Diisopropylamine dichloroacetate, a novel pyruvate dehydrogenase kinase 4 inhibitor, as a potential therapeutic agent for metabolic disorders and multiorgan failure in severe influenza. PLoS One 9:e98032 (2014). Functional Studies . PubMed: 24865588
  • Sheriff S  et al. Des-acyl-ghrelin (DAG) normalizes hyperlactacidemia and improves survival in a lethal rat model of burn trauma. Peptides 60:1-7 (2014). Rat . PubMed: 25063053
  • Hamabe A  et al. Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1a in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis. Cancer Sci 105:1100-8 (2014). PubMed: 25060325
  • van der Veen JN  et al. The concentration of phosphatidylethanolamine in mitochondria can modulate ATP production and glucose metabolism in mice. Diabetes 63:2620-30 (2014). Mouse . PubMed: 24677714
  • Kageyama Y  et al. Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain. EMBO J 33:2798-813 (2014). PubMed: 25349190
  • Morten KJ  et al. Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts. J Pathol 229:755-64 (2013). PubMed: 23303559
  • Phillips BE  et al. Effect of colon cancer and surgical resection on skeletal muscle mitochondrial enzyme activity in colon cancer patients: a pilot study. J Cachexia Sarcopenia Muscle 4:71-7 (2013). Functional Studies ; Human . PubMed: 22648738
  • Geng X  et al. Synergetic neuroprotection of normobaric oxygenation and ethanol in ischemic stroke through improved oxidative mechanism. Stroke 44:1418-25 (2013). PubMed: 23512978
  • Gu F  et al. Alterations in mitochondrial DNA copy number and the activities of electron transport chain complexes and pyruvate dehydrogenase in the frontal cortex from subjects with autism. Transl Psychiatry 3:e299 (2013). PubMed: 24002085
  • Jing E  et al. Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes 62:3404-17 (2013). PubMed: 23835326
  • Eckle T  et al. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol 11:e1001665 (2013). PubMed: 24086109
  • Ota A  et al. Effects of aripiprazole and clozapine on the treatment of glycolytic carbon in PC12 cells. J Neural Transm : (2012). PubMed: 22392058
  • Thomas SN  et al. Quantitative proteomic analysis of mitochondrial proteins reveals prosurvival mechanisms in the perpetuation of radiation-induced genomic instability. Free Radic Biol Med 53:618-28 (2012). PubMed: 22569412
  • Hong JK  et al. Growth factor withdrawal in combination with sodium butyrate addition extends culture longevity and enhances antibody production in CHO cells. J Biotechnol 155:225-31 (2011). Chinese hamster . PubMed: 21723342
  • Yi X  et al. Genetic reduction of lipoic acid synthase expression modestly increases atherosclerosis in male, but not in female, apolipoprotein E-deficient mice. Atherosclerosis 211:424-30 (2010). PubMed: 20347443
  • Puthanveetil P  et al. The increase in cardiac pyruvate dehydrogenase kinase-4 after short-term dexamethasone is controlled by an Akt-p38-forkhead box other factor-1 signaling axis. Endocrinology 151:2306-18 (2010). PubMed: 20181797
  • Lee DW  et al. Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease. J Biol Chem 284:29065-76 (2009). PubMed: 19679656
  • Sikder D & Kodadek T The neurohormone orexin stimulates hypoxia-inducible factor-1 activity. Genes Dev 21:2995-3005 (2007). PubMed: 18006690

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