Overview

  • Product name

    QNZ, NF-kB inhibitor
  • Description

    Potent, selective NF-kB inhibitor
  • Biological description

    Potent, selective NF-kB inhibitor (IC50 = 11 nM). Inhibits LPS-induced TNFα production (IC50 = 7 nM). Reduces edema in inflammation in vivo.
  • Purity

    > 98%
  • CAS Number

    545380-34-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Lai TY  et al. 17beta-estradiol inhibits prostaglandin E2-induced COX-2 expressions and cell migration by suppressing Akt and ERK1/2 signaling pathways in human LoVo colon cancer cells. Mol Cell Biochem 342:63-70 (2010). Read more (PubMed: 20446020) »
  • Choi S  et al. Nuclear factor-kappaB activated by capacitative Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells. J Biol Chem 281:12722-8 (2006). Read more (PubMed: 16490783) »
  • Tobe M  et al. A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives. Bioorg Med Chem 11:3869-78 (2003). Read more (PubMed: 12927847) »

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