Overview

  • Product name

    QS11, ARFGAP1 inhibitor
  • Description

    ARFGAP1 inhibitor. Wnt/β-catenin pathway modulator.
  • Biological description

    Potent GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor (EC50 = 0.5 μM). Wnt/β-catenin pathway modulator. Antitumor agent. Active in vitro.
  • Purity

    > 98%
  • CAS Number

    944328-88-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kim W  et al. ADP-ribosylation factors 1 and 6 regulate Wnt/ß-catenin signaling via control of LRP6 phosphorylation. Oncogene 32:3390-6 (2013). Read more (PubMed: 22907437) »
  • Zhu W  et al. Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability. Nature 492:252-5 (2012). Read more (PubMed: 23143332) »
  • Zhang Q  et al. Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A 104:7444-8 (2007). Read more (PubMed: 17460038) »

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