Overview

  • Product name

    Quetiapine hemifumarate, D2 and 5-HT2 antagonis
  • Description

    D2 and 5-HT2 antagonist. Antipsychotic.
  • Biological description

    D2 and 5-HT2 antagonist. IC50 values (nM) are 329 (D2), 1243 (D1), 148 (5-HT2), 720 (5-HT1A), 90 (α1), 270 (α2), muscarinic (>10,000) and benzodiazepine (>10,000). Antipsychotic. Centrally active following oral administration.
  • Purity

    > 99%
  • CAS Number

    111974-72-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • King DJ  et al. A comparison of bd and tid dose regimens of quetiapine (Seroquel) in the treatment of schizophrenia. Psychopharmacology (Berl) 137:139-46 (1998). Read more (PubMed: 9630000) »
  • Saller CF & Salama AI Seroquel: biochemical profile of a potential atypical antipsychotic. Psychopharmacology (Berl) 112:285-92 (1993). Read more (PubMed: 7871032) »

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