Quinacrine mustard dihydrochloride, Fluorescent probe for labeling chromosomal DNA (ab145375)

Overview

  • Product name

    Quinacrine mustard dihydrochloride, Fluorescent probe for labeling chromosomal DNA
  • Description

    Water-soluble fluorescent probe for labeling chromosomal DNA.
  • Alternative names

    • 9-[4-(Bis(2-chloroethyl)amino)-1-methylbutylamino]-6-chloro-2-methoxyacridine dihydrochloride
    • Atabrine mustard dihydrochloride
    • NSC 3424
    • QM dihydrochloride
  • Biological description

    Water-soluble nitrogen mustard analog of quinacrine (ab120749). Fluorescent probe for labeling chromosomal DNA. Fluoresces by reaction with nucleic acids. Also used in measurement of sequence specificity with Taq DNA polymerase.

  • Purity

    > 95%
  • CAS Number

    4213-45-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Methoxy-6-chloro-9-[4-bis(2-chloroethyl)amino-1-methylbutylamino]acridine dihydrochloride
  • Molecular weight

    541.80
  • Molecular formula

    C23H28Cl3N3O.2HCl
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Inuma M  et al. The role of nick formation in delayed quinacrine mustard fluorescence in the C-heterochromatin of Apodemus argenteus. Zoolog Sci 26:344-8 (2009). Read more (PubMed: 19715504) »
  • Ponti M  et al. Measurement of the sequence specificity of covalent DNA modification by antineoplastic agents using Taq DNA polymerase. Nucleic Acids Res 19:2929-33 (1991). Read more (PubMed: 2057351) »
  • Adachi H [Studies on sex determination using human dental pulp. I. The observation of Y-chromatin for the paraffin section using quinacrine mustard staining]. Nihon Hoigaku Zasshi 42:38-41 (1988). Read more (PubMed: 3411799) »
  • Hauser-Urfer I  et al. Cytofluorometric determination of the DNA base content in human chromosomes with quinacrine mustard, Hoechst 33'258, DAPI, and mithramycin. Exp Cell Res 142:455-9 (1982). Read more (PubMed: 6184241) »
  • Selander RK Interaction of quinacrine mustard with mononucleotides and polynucleotides. Biochem J 131:749-55 (1973). Read more (PubMed: 4578946) »
  • Caspersson T  et al. Fluorescent labeling of chromosomal DNA: superiority of quinacrine mustard to quinacrine. Science 170:762 (1970). Read more (PubMed: 5479635) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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