Overview

  • Product name
    Quinol 1h, Antitumor agent
  • Description
    Potent, selective antitumor agent
  • Biological description
    Potent, selective antitumor agent. Antitumor activity observed in HCT 116 (GI50 = 40 nM) and HT 29 (GI50 = 380 nM), and in breast cancer cell lines. Potent inhibitory effect in NCI 60 cells (GI50 =16 nM and LC50 = 2.24 µM). Active in vitro.
  • Purity
    > 99%
  • General notes
    Sold under license from CRT
  • CAS Number
    840474-95-5
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    4-[1-(Benzenesulfonyl)-6-fluoro-1H-indol-2-yl]-4-hydroxycyclohexa-2,5-dien-1-one
  • Molecular weight
    383.39
  • Molecular formula
    C20H14FNO4S
  • PubChem identifier
    9907134
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    O=C(C=C1)C=CC1(O)C2=CC3=C(N2S(=O)(C4=CC=CC=C4)=O)C=CC=C3
  • Source

    Synthetic

References

This product has been referenced in:
  • Capes A  et al. Quinol derivatives as potential trypanocidal agents. Bioorg Med Chem 20:1607-15 (2012). Read more (PubMed: 22264753) »
  • Berry JM  et al. Quinols as novel therapeutic agents. 2.(1) 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents. J Med Chem 48:639-44 (2005). Read more (PubMed: 15658878) »
  • Wells G  et al. 4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines. J Med Chem 46:532-41 (2003). Read more (PubMed: 12570375) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144639.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up