Overview

  • Product name
    QVD-OPh
  • Description
    Potent, cell-permeable, irreversible broad-spectrum caspase inhibitor
  • Biological description
    Potent, cell-permeable, irreversible broad-spectrum caspase inhibitor (IC50 values are 25, 50, 100 and 430 nM for caspase-3, 1, 8 and 9 respectively). Inhibits apoptosis. Shows anti-ischemic and neuroprotective effects in vivo. Blood-brain barrier permeable.
  • Purity
    > 95%

Properties

References

This product has been referenced in:
  • Han W  et al. Delayed, long-term administration of the caspase inhibitor Q-VD-OPh reduced brain injury induced by neonatal hypoxia-ischemia. Dev Neurosci 36:64-72 (2014). Read more (PubMed: 24525800) »
  • Chaabane W  et al. Human-gyrovirus-Apoptin triggers mitochondrial death pathway--Nur77 is required for apoptosis triggering. Neoplasia 16:679-93 (2014). Read more (PubMed: 25246270) »
  • Lee DW  et al. A pan caspase inhibitor decreases caspase-1, IL-1a and IL-1ß, and protects against necrosis of cisplatin-treated freshly isolated proximal tubules. Ren Fail :1-7 (2014). Read more (PubMed: 25310769) »

Customer reviews and Q&As

Question
Answer


This inhibitor is a broad caspase inhibitor.
Please see the below publication for more details:

http://www.ncbi.nlm.nih.gov/pubmed/12815277

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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