DescriptionPotent, cell-permeable, irreversible broad-spectrum caspase inhibitor
Biological descriptionPotent, cell-permeable, irreversible broad-spectrum caspase inhibitor (IC50 values are 25, 50, 100 and 430 nM for caspase-3, 1, 8 and 9 respectively). Inhibits apoptosis. Shows anti-ischemic and neuroprotective effects in vivo. Blood-brain barrier permeable.
SequenceVD (Modifications: N-terminal quinolyl; C-terminal OPh)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Research Area
- Alzheimer's Disease
- Signal transduction
- Hedgehog signaling
This product has been referenced in:
- Han W et al. Delayed, long-term administration of the caspase inhibitor Q-VD-OPh reduced brain injury induced by neonatal hypoxia-ischemia. Dev Neurosci 36:64-72 (2014). Read more (PubMed: 24525800) »
- Chaabane W et al. Human-gyrovirus-Apoptin triggers mitochondrial death pathway--Nur77 is required for apoptosis triggering. Neoplasia 16:679-93 (2014). Read more (PubMed: 25246270) »
- Lee DW et al. A pan caspase inhibitor decreases caspase-1, IL-1a and IL-1ß, and protects against necrosis of cisplatin-treated freshly isolated proximal tubules. Ren Fail :1-7 (2014). Read more (PubMed: 25310769) »