Overview

  • Product name

    QVD-OPh (DMSO solution), caspase inhibitor
  • Description

    Potent, cell-permeable, irreversible broad-spectrum caspase inhibitor
  • Biological description

    Potent, cell-permeable, irreversible broad-spectrum caspase inhibitor (IC50 values are 25, 50, 100 and 430 nM for caspase-3, 1, 8 and 9 respectively). Inhibits apoptosis. Shows anti-ischemic and neuroprotective effects in vivo. Blood-brain barrier permeable.

    Also available as a solid (ab141421).
  • Purity

    > 95%
  • CAS Number

    1135695-98-5
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    513.49
  • Molecular formula

    C26H25F2N3O6
  • Sequence

    VD (Modifications: N-terminal quinolyl; C-terminal OPh)
  • PubChem identifier

    11237609
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Supplied in DMSO (10 mM)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)C(C(=O)NC(CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Han W  et al. Delayed, long-term administration of the caspase inhibitor Q-VD-OPh reduced brain injury induced by neonatal hypoxia-ischemia. Dev Neurosci 36:64-72 (2014). Read more (PubMed: 24525800) »
  • de Araujo CB  et al. A novel intracellular peptide derived from g1/s cyclin d2 induces cell death. J Biol Chem 289:16711-26 (2014). Read more (PubMed: 24764300) »
  • Lim EJ  et al. Hepatitis C virus-induced hepatocyte cell death and protection by inhibition of apoptosis. J Gen Virol 95:2204-15 (2014). Read more (PubMed: 24973240) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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