Key features and details
- Na+ channel blocker. 1 ml water soluble pack.
- CAS Number: 21306-56-9
- Purity: > 99%
- Soluble in 1 ml water to give specified mM/ml concentration
- Form / State: Solid
- Source: Synthetic
Product nameQX-314 bromide (N-Ethyllidocaine bromide) (mM/ml), Na+ channel blocker
DescriptionNa+ channel blocker. 1 ml water soluble pack.
- N-Ethyllidocaine bromide
A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ conductance when applied intracellularly.
Soluble in 1 ml water to give specified mM/ml concentration. Find out more.
Chemical nameN-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in 1 ml water to give specified mM/ml concentration
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144492 has been referenced in 8 publications.
- Puopolo M et al. Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314. J Neurophysiol 109:1704-12 (2013). PubMed: 23303863
- Jeong HJ et al. Serotonergic modulation of neuronal activity in rat midbrain periaqueductal gray. J Neurophysiol 109:2712-9 (2013). PubMed: 23515792
- Quattrocolo G & Maccaferri G Novel GABAergic circuits mediating excitation/inhibition of Cajal-Retzius cells in the developing hippocampus. J Neurosci 33:5486-98 (2013). PubMed: 23536064
- Riebe I & Hanse E Development of synaptic connectivity onto interneurons in stratum radiatum in the CA1 region of the rat hippocampus. BMC Neurosci 13:14 (2012). PubMed: 22276909
- Kawahara H et al. Inhibition of fatty acid amide hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey. Br J Pharmacol 163:1214-22 (2011). PubMed: 21175570
- Le Duigou C & Kullmann DM Group I mGluR agonist-evoked long-term potentiation in hippocampal oriens interneurons. J Neurosci 31:5777-81 (2011). PubMed: 21490219
- Case DT & Gillespie DC Pre- and postsynaptic properties of glutamatergic transmission in the immature inhibitory MNTB-LSO pathway. J Neurophysiol 106:2570-9 (2011). PubMed: 21832038
- Jeong HJ et al. N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn. Br J Pharmacol 161:925-35 (2010). PubMed: 20860669