QX-314 bromide (N-Ethyllidocaine bromide) (mM/ml), Na+ channel blocker (ab144492)

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Overview

  • Product name

    QX-314 bromide (N-Ethyllidocaine bromide) (mM/ml), Na+ channel blocker

  • Description

    Na+ channel blocker. 1 ml water soluble pack.

  • Alternative names

    • N-Ethyllidocaine bromide

  • Biological description

    A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ conductance when applied intracellularly.

    Soluble in 1 ml water to give specified mM/ml concentration. Find out more.

  • Purity

    > 99%

  • CAS Number

    21306-56-9

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide

  • Molecular weight

    343.31

  • Molecular formula

    C16H27BrN2O

  • PubChem identifier

    9884487

  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in 1 ml water to give specified mM/ml concentration

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [Br-].O=C(Nc1c(C)cccc1C)C[N+](CC)(CC)CC

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Colling SB & Wheal HV Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells. Neurosci Lett 172:73-96 (1994). Read more (PubMed: 8084540) »
  • Butterworth J  et al. Inhibition of brain cell excitability by lidocaine, QX314, and tetrodotoxin: a mechanism for analgesia from infused local anesthetics? Acta Anaesthesiol Scand 37:516-23 (1993). Read more (PubMed: 8356868) »
  • Strichartz GR The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J Gen Physiol 62:37-57 (1973). Read more (PubMed: 4541340) »
See all 8 Publications for this product

Publishing research using ab144492? Please let us know so that we can cite the reference in this datasheet.

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