QX-314 chloride (N-Ethyllidocaine chloride) (mM/ml), Na+ channel blocker (ab144493)

Overview

  • Product name

    QX-314 chloride (N-Ethyllidocaine chloride) (mM/ml), Na+ channel blocker
  • Description

    Na+ channel blocker. 1 ml water soluble pack.
  • Alternative names

    • N-Ethyllidocaine chloride
  • Biological description

    A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ channels.

    Soluble in 1 ml water to give specified mM/ml concentration. Find out more.
  • Purity

    > 99%
  • CAS Number

    5369-03-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
  • Molecular weight

    298.85
  • Molecular formula

    C16H27ClN2O
  • PubChem identifier

    21462
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 1 ml water to give specified mM/ml concentration
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [Cl-].O=C(Nc1c(C)cccc1C)C[N+](CC)(CC)CC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Colling SB & Wheal HV Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells. Neurosci Lett 172:73-96 (1994). Read more (PubMed: 8084540) »
  • Butterworth J  et al. Inhibition of brain cell excitability by lidocaine, QX314, and tetrodotoxin: a mechanism for analgesia from infused local anesthetics? Acta Anaesthesiol Scand 37:516-23 (1993). Read more (PubMed: 8356868) »
  • Strichartz GR The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J Gen Physiol 62:37-57 (1973). Read more (PubMed: 4541340) »
See all 4 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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