Key features and details
- Na+ channel blocker
- CAS Number: 5369-03-9
- Purity: > 99%
- Soluble in water to 100 mM and to 50 mM in DMSO
- Form / State: Solid
- Source: Synthetic
Product nameQX-314 chloride (N-Ethyllidocaine chloride), Na+ channel blocker
DescriptionNa+ channel blocker
- N-Ethyllidocaine chloride
A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ channels.
Also available in simple stock solutions (ab144493) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical nameN-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM and to 50 mM in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120118 has been referenced in 11 publications.
- Vaden RJ et al. Parvalbumin interneurons provide spillover to newborn and mature dentate granule cells. Elife 9:N/A (2020). PubMed: 32602839
- Weyrer C et al. The Role of CaV2.1 Channel Facilitation in Synaptic Facilitation. Cell Rep 26:2289-2297.e3 (2019). PubMed: 30811980
- Vaden JH et al. The readily-releasable pool dynamically regulates multivesicular release. Elife 8:N/A (2019). PubMed: 31364987
- Han KS et al. Ephaptic Coupling Promotes Synchronous Firing of Cerebellar Purkinje Cells. Neuron 100:564-578.e3 (2018). PubMed: 30293822
- Hernández VM et al. Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus. J Neurosci 35:11830-47 (2015). PubMed: 26311767