R-(-)-alpha-Methylhistamine dihydrobromide, H3 receptor agonist (ab120774)

Overview

  • Product name

    R-(-)-alpha-Methylhistamine dihydrobromide, H3 receptor agonist
  • Description

    Highly potent, selective H3 receptor agonist
  • Biological description

    Highly potent, selective H3 receptor agonist (Kd = 50 nM). Induces H4-mediated eosinophil shape change (EC50 = 66 nM). Inhibits H3-mediated histamine synthesis and release in the CNS. Active in vivo.
  • Purity

    > 99%
  • CAS Number

    75614-87-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(1H-Imidazol-5-yl)propan-2-amine dihydrobromide
  • Molecular weight

    287.00
  • Molecular formula

    C6H11N3.2HBr
  • PubChem identifier

    206868
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(CC1=CN=CN1)N.Br.Br
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Francis H  et al. H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo. Mol Cancer Res 7:1704-13 (2009). Read more (PubMed: 19825989) »
  • Francis H  et al. H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway. Lab Invest 87:473-87 (2007). Read more (PubMed: 17334413) »
  • Oishi R  et al. Effects of the histamine H3-agonist (R)-alpha-methylhistamine and the antagonist thioperamide on histamine metabolism in the mouse and rat brain. J Neurochem 52:1388-92 (1989). Read more (PubMed: 2540269) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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