Key features and details
- Selective full 5-HT1A receptor agonist
- CAS Number: 78095-19-9
- Purity: > 98%
- Soluble in water to 20 mM
- Form / State: Solid
- Source: Synthetic
Product name(R)-(+)-8-Hydroxy-DPAT hydrobromide (8-Hydroxy DPAT), 5-HT1A receptor agonist
DescriptionSelective full 5-HT1A receptor agonist
- 8-Hydroxy DPAT
Selective full 5-HT1A receptor agonist. More active enantiomer of 8-OH-DPAT. Displays greater efficacy at 5-HT1A. Also displays moderate affinity at 5-HT7. Inhibits amphetamine induced dopamine release.
Chemical name(2R)-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 20 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120507 has been referenced in 1 publication.
- Qian YW et al. HIV-1 gp120 Glycoprotein Interacting with Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN) Down-Regulates Tight Junction Proteins to Disrupt the Blood Retinal Barrier and Increase Its Permeability. J Biol Chem 291:22977-22987 (2016). PubMed: 27605665