R-(+)-Cotinine, chiral primary nicotine metabolite (ab144738)

Overview

  • Product name

    R-(+)-Cotinine, chiral primary nicotine metabolite
  • Description

    Chiral primary nicotine metabolite. Neuronal nAChR agonist.
  • Biological description

    Chiral primary nicotine (ab145110, ab145013, ab120562, ab120450) metabolite. Neuronal nAChR agonist. Shows a much longer half life of 20 hours than nicotine. Shows carcinogenic effects. Improves sustained attention and decreasing impulsive and compulsive behaviours. Shows antipsychotic effects in vivo. Blood-brain barrier permeable.
  • CAS Number

    32162-64-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (5R)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one
  • Molecular weight

    176.22
  • Molecular formula

    C10H12N2O
  • PubChem identifier

    21907
  • Storage instructions

    Store at -20°C. Store In the Dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Soluble in water and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1[C@H](CCC1=O)C2=CN=CC=C2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Craig EL  et al. Nicotine pharmacokinetics in rats is altered as a function of age, impacting the interpretation of animal model data. Drug Metab Dispos 42:1447-55 (2014). Read more (PubMed: 24980255) »
  • Tsuji H  et al. Comparison of biological responses in rats under various cigarette smoke exposure conditions. J Toxicol Pathol 26:159-74 (2013). Read more (PubMed: 23914058) »
  • Terry AV  et al. The nicotine metabolite, cotinine, attenuates glutamate (NMDA) antagonist-related effects on the performance of the five choice serial reaction time task (5C-SRTT) in rats. Biochem Pharmacol 83:941-51 (2012). Read more (PubMed: 22244928) »

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