Overview

  • Product name

    (R)-(+)-Etomoxir, CPT1 inhibitor
  • Description

    CPT1 inhibitor
  • Biological description

    CPT1 inhibitor. Inhibits β-oxidation in mitochondria (IC50 values are 0.1, 1 and 10 μM for human, guinea pig and rat hepatocytes respectively). Putative antidiabetic agent.
  • CAS Number

    124083-20-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Ethyl (2R)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate
  • Molecular weight

    326.81
  • Molecular formula

    C17H23ClO4
  • PubChem identifier

    9840324
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 20 mM and in DMSO to 20 mM (with gentle warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCOC(=O)[C@]1(CO1)CCCCCCOC2=CC=C(C=C2)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Najafi M Effects of Postconditioning, Preconditioning and Perfusion of L-carnitine During Whole Period of Ischemia/ Reperfusion on Cardiac Hemodynamic Functions and Myocardial Infarction Size in Isolated Rat Heart. Iran J Basic Med Sci 16:648-55 (2013). Read more (PubMed: 24250945) »
  • Vincourt V  et al. Altered HepG2 cell models using etomoxir versus tert-butylhydroperoxide. Cell Biol Toxicol 27:363-70 (2011). Read more (PubMed: 21706388) »
  • Agius L  et al. Differences between human, rat and guinea pig hepatocyte cultures. A comparative study of their rates of beta-oxidation and esterification of palmitate and their sensitivity to R-etomoxir. Biochem Pharmacol 42:1711-5 (1991). Read more (PubMed: 1930297) »

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