(R)-Bicalutamide, androgen receptor antagonist (ab142460)
- Datasheet
- References
Overview
-
Product name
(R)-Bicalutamide, androgen receptor antagonist -
Description
Non-steroidal androgen receptor antagonist -
Biological description
Non-steroidal androgen receptor antagonist. (R)-Enantiomer of antiandrogen Bicalutamide (Asc 1249). Stimulates AR-mediated transcription. Orally active. -
Purity
> 98% -
CAS Number
113299-40-4 -
Chemical structure
Properties
-
Chemical name
(2R)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methylpropanamide -
Molecular weight
430.37 -
Molecular formula
C18H14F4N2O4S -
PubChem identifier
56069 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O -
Source
Synthetic
-
Research areas
References
This product has been referenced in:
- Hwang DJ et al. Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer. Bioorg Med Chem 14:6525-38 (2006). Read more (PubMed: 16828557) »
- Bohl CE et al. Structural basis for accommodation of nonsteroidal ligands in the androgen receptor. J Biol Chem 280:37747-54 (2005). Read more (PubMed: 16129672) »
- Mukherjee A et al. Affinity labeling of the androgen receptor with nonsteroidal chemoaffinity ligands. Biochem Pharmacol 58:1259-67 (1999). Read more (PubMed: 10487527) »
