Overview

  • Product name

    (R)-CPP (mM/ml), NMDA antagonist
  • Description

    Potent NMDA antagonist. 1 ml water soluble pack.
  • Biological description

    Highly potent, competitive NMDA antagonist; more active enantiomer of (RS)-CPP (ab120160). (Ki values are 0.04, 0.3, 0.6 and 2.0 μM at NR1/NR2A, NR1/NR2B, NR1/NR2C and NR1/NR2D, respectively).

    Soluble in 1 ml water to give specified mM/ml concentration. Find out more.
  • CAS Number

    126453-07-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (R)-3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid
  • Molecular weight

    252.20
  • Molecular formula

    C8H17N2O5P
  • PubChem identifier

    6603754
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 1 ml water to give specified mM/ml concentration
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(O)[C@H]1CN(CCCP(=O)(O)O)CCN1
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Paoletti P & Neyton J NMDA receptor subunits: function and pharmacology. Curr Opin Pharmacol 7:39-47 (2007). Read more (PubMed: 17088105) »
  • Lowe DA  et al. D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci Lett 113:315-21 (1990). Read more (PubMed: 2166255) »
See all 6 Publications for this product

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