Key features and details
- Potent, ATP-competitive cdk and CK1 inhibitor
- CAS Number: 1241675-76-2
- Purity: > 98%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product name(R)-DRF053 dihydrochloride, CDK and CK1 inhibitor
DescriptionPotent, ATP-competitive cdk and CK1 inhibitor
Potent, ATP-competitive cdk and CK1 inhibitor (IC50 values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1, respectively and 4.1 μM for GSK α/β). Inhibits amyloid-β production.
Also available in simple stock solutions (ab146736) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical name(2R)-2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanol dihydrochloride
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141505 has not yet been referenced specifically in any publications.