(R)-Flurbiprofen (Tarenflurbil), gamma-secretase inhibitor (ab144471)

Overview

  • Product name

    (R)-Flurbiprofen (Tarenflurbil), gamma-secretase inhibitor
  • Description

    γ-secretase inhibitor
  • Alternative names

    • Tarenflurbil
  • Biological description

    γ-secretase inhibitor. Flurbiprofen (ab142877) enantiomer. Inactive towards COX. Inhibits NF-κB and AP-1 activation. Prevents Aβ42 formation and shows anti-inflammatory and neuroprotective effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    51543-40-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Schmitz K  et al. R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice. EMBO Mol Med 6:1398-422 (2014). Read more (PubMed: 25269445) »
  • Carreras I  et al. R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease. Brain Res 1541:115-27 (2013). Read more (PubMed: 24161403) »
  • Liu JL  et al. Flurbiprofen axetil promotes neuroprotection by activation of cerebral peroxisome proliferator-activated receptor gamma after focal cerebral ischemia in rats. Chin Med J (Engl) 125:3719-24 (2012). Read more (PubMed: 23075731) »

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