Product name(R)-FSL-1, TLR2/6 agonist
DescriptionTLR2/6 agonist. Synthetic lipoprotein.
Biological descriptionToll-like receptor 2/6 (TLR2/6) agonist. Synthetic lipoprotein. Represents N-terminal part of Mycoplasma salivarium LP44. NF-κB and MAPK pathway activator. Active in vivo. R stereoisomer of FSL-1 (ab144863).
SequenceCGDPKHPKSF (Modifications: Cys-1 = S-(2,3-bis(palmitoyloxy)-(2R)-propyl)Cys))
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 5 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Long EM et al. Lipoteichoic acid induces unique inflammatory responses when compared to other toll-like receptor 2 ligands. PLoS One 4:e5601 (2009). Read more (PubMed: 19440307) »
- Rose WA et al. FSL-1, a bacterial-derived toll-like receptor 2/6 agonist, enhances resistance to experimental HSV-2 infection. Virol J 6:195 (2009). Read more (PubMed: 19903337) »
- Shibata K et al. The N-terminal lipopeptide of a 44-kDa membrane-bound lipoprotein of Mycoplasma salivarium is responsible for the expression of intercellular adhesion molecule-1 on the cell surface of normal human gingival fibroblasts. J Immunol 165:6538-44 (2000). Read more (PubMed: 11086096) »