• Product name

  • Description

    Rabbit polyclonal to RAB3GAP1
  • Host species

  • Specificity

    ab74447 detects endogenous levels of total RAB3GAP1 protein. Does not react with mouse samples, by honology and testing for NIH3T3
  • Tested applications

    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Does not react with: Mouse
  • Immunogen

    Synthetic peptide derived from an internal region of human RAB3GAP1.

  • Positive control

    • Human testis tissue; 293 cell extracts.



Our Abpromise guarantee covers the use of ab74447 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 111 kDa.
ELISA 1/40000.
IHC-P 1/50 - 1/100.


  • Function

    Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
  • Tissue specificity

  • Involvement in disease

    Defects in RAB3GAP1 are the cause of Warburg micro syndrome type 1 (WARBM1) [MIM:600118]. A rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism.
  • Sequence similarities

    Belongs to the Rab3-GAP catalytic subunit family.
  • Cellular localization

    Cytoplasm. In neurons, it is enriched in the synaptic soluble fraction.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp434A012 antibody
    • KIAA0066 antibody
    • P130 antibody
    • Rab3 GAP antibody
    • Rab3 GAP p130 antibody
    • RAB3 GTPase activating protein 130 kDa subunit antibody
    • Rab3 GTPase activating protein catalytic subunit antibody
    • RAB3 GTPase activating protein subunit 1 (catalytic) antibody
    • RAB3 GTPase-activating protein 130 kDa subunit antibody
    • Rab3 GTPase-activating protein catalytic subunit antibody
    • Rab3-GAP antibody
    • Rab3-GAP p130 antibody
    • RAB3GAP antibody
    • rab3gap1 antibody
    • RAB3GAP130 antibody
    • RB3GP_HUMAN antibody
    • WARBM1 antibody
    see all


  • ab74447, at a 1/50 dilution, staining RAB3GAP1 in paraffin embedded human testis tissue by Immunohistochemistry in the absence (left image) or presence (right image) of the immunizing peptide.
  • All lanes : Anti-RAB3GAP1 antibody (ab74447) at 1/500 dilution

    Lane 1 : 293 cell extracts
    Lane 2 : 293 cell extracts with immunizing peptide at 10 µg

    Lysates/proteins at 5 µg per lane.

    Predicted band size: 111 kDa
    Observed band size: 111 kDa


ab74447 has not yet been referenced specifically in any publications.

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