Anti-RAB3GAP1 antibody - C-terminal (ab229589)

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Western blot - Anti-RAB3GAP1 antibody - C-terminal (ab229589)

    Key features and details

    • Rabbit polyclonal to RAB3GAP1 - C-terminal
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-RAB3GAP1 antibody - C-terminal
      See all RAB3GAP1 primary antibodies

    • Description

      Rabbit polyclonal to RAB3GAP1 - C-terminal

    • Host species

      Rabbit

    • Tested Applications & Species

      Application Species
      WB
      Human
      See all applications and species data

    • Immunogen

      Recombinant fragment within Human RAB3GAP1 (C terminal). The exact sequence is proprietary.
      Database link: Q15042

    • Positive control

      • WB: HEK-293T, A431, HeLa and HepG2 whole cell extracts.

    Properties

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab229589 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    WB
    Human
    All applications
    Mouse
    Cow
    Xenopus laevis
    Application Abreviews Notes
    WB
    1/500 - 1/3000.
    Notes
    WB
    1/500 - 1/3000.

    Target

    • Function

      Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.

    • Tissue specificity

      Ubiquitous.

    • Involvement in disease

      Defects in RAB3GAP1 are the cause of Warburg micro syndrome type 1 (WARBM1) [MIM:600118]. A rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism.

    • Sequence similarities

      Belongs to the Rab3-GAP catalytic subunit family.

    • Cellular localization

      Cytoplasm. In neurons, it is enriched in the synaptic soluble fraction.
    • Information by UniProt

    • Database links

      see all

    • Alternative names

      • DKFZp434A012 antibody
      • KIAA0066 antibody
      • P130 antibody
      • Rab3 GAP antibody
      • Rab3 GAP p130 antibody
      • RAB3 GTPase activating protein 130 kDa subunit antibody
      • Rab3 GTPase activating protein catalytic subunit antibody
      • RAB3 GTPase activating protein subunit 1 (catalytic) antibody
      • RAB3 GTPase-activating protein 130 kDa subunit antibody
      • Rab3 GTPase-activating protein catalytic subunit antibody
      • Rab3-GAP antibody
      • Rab3-GAP p130 antibody
      • RAB3GAP antibody
      • rab3gap1 antibody
      • RAB3GAP130 antibody
      • RB3GP_HUMAN antibody
      • WARBM1 antibody
      see all

    Images

    • Western blot - Anti-RAB3GAP1 antibody - C-terminal (ab229589)
      Western blot - Anti-RAB3GAP1 antibody - C-terminal (ab229589)
      All lanes : Anti-RAB3GAP1 antibody - C-terminal (ab229589) at 1/1000 dilution

      Lane 1 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell extract
      Lane 2 : A431 (human epidermoid carcinoma cell line) whole cell extract
      Lane 3 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell extract
      Lane 4 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell extract

      Lysates/proteins at 30 µg per lane.


      7.5% SDS-PAGE gel.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab229589? Please let us know so that we can cite the reference in this datasheet.

    ab229589 has not yet been referenced specifically in any publications.

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