Key features and details
- Mouse polyclonal to RAB7B
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-RAB7B antibody
See all RAB7B primary antibodies
DescriptionMouse polyclonal to RAB7B
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Recombinant full length human RAB7B (aa 1-199; AAH17092.1).
- RAB7B transfected 293T cell lysate.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.20
Constituent: 2.68% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab77064 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 - 5 µg/ml. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa).|
FunctionControls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
Tissue specificityExpressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.
Sequence similaritiesBelongs to the small GTPase superfamily. Rab family.
Cellular localizationLate endosome. Lysosome. Golgi apparatus > trans-Golgi network. Golgi apparatus.
- Information by UniProt
- MGC16212 antibody
- MGC9726 antibody
- RAB7 antibody
All lanes : Anti-RAB7B antibody (ab77064) at 5 µg/ml
Lane 1 : RAB7B transfected 293T cell lysate
Lane 2 : Non-transfected transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
All lanes : Goat anti-Mouse IgG (H&L)-HRP at 1/2500 dilution
Predicted band size: 22 kDa
Observed band size: 22 kDa
ab77064 has not yet been referenced specifically in any publications.