Key features and details
- Potent and selective irreversible gastric H+/K+ ATPase pump inhibitor
- CAS Number: 117976-90-6
- Purity: > 98%
- Soluble in water to 25 mM and in ethanol to 75 mM
- Form / State: Solid
- Source: Synthetic
Product nameRabeprazole sodium salt, gastric H+/K+ ATPase pump inhibitor
DescriptionPotent and selective irreversible gastric H+/K+ ATPase pump inhibitor
Biological descriptionPotent and selective irreversible gastric H+/K+ ATPase pump inhibitor (IC50 = 72 nM). Prodrug of sulphenamide. Activates over a greater pH range than omeprazole (ab142993). Shows antibacterial effects against H. pylori (IC50 = 290 nM). Prevents the production of stomach acid in vivo. Orally active.
Chemical name2-[[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]benzimidazol-1-ide sodium salt
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 25 mM and in ethanol to 75 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab143690 has been referenced in 1 publication.
- Liu J et al. A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIß Signaling in Limb Girdle Muscular Dystrophy. Cell Rep Med 1:100122 (2020). PubMed: 33205074