Overview

  • Product name

    Anti-RAD21L1 antibody
  • Description

    Rabbit polyclonal to RAD21L1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to amino acids 339-419 of Human RAD21L1 (Uniprot: Q9H410).

  • Positive control

    • Human ovary tissue
  • General notes

    ab151174 should be gently mixed before use.

Properties

Applications

Our Abpromise guarantee covers the use of ab151174 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Relevance

    Function: Meiosis-specific component of some cohesin complex. Probably required during early meiosis for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. May be involved in synapsis initiation and crossover recombination between homologous chromosomes. Subunit structure: Component of some meiotic cohesin complex composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21L which link them, and STAG3. Sequence similarities Belongs to the rad21 family.
  • Cellular localization

    Nucleus. Chromosome. Note: In meiotic chromosomes, localized along axial elements in early meiosis: detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. It then disappears and is replaced with RAD21. Compared to REC8, has mutually exclusive loading sites on the chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains along the axial elements
  • Database links

  • Alternative names

    • dJ545L17.2 antibody
    • Double-strand-break repair protein rad21-like protein 1 antibody
    • RAD21L antibody
    • RP11-314N13.7 antibody

Images

  • Immunohistochemical analysis of Paraffin-embedded Human ovary tissue labeling RAD21L1 with ab151174 at 1/50 dilution.

References

ab151174 has not yet been referenced specifically in any publications.

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