Radicicol, Heat shock protein (HSP) 90 inhibitor (ab141848)

Overview

  • Product name

    Radicicol, Heat shock protein (HSP) 90 inhibitor
  • Description

    Heat shock protein 90 inhibitor. Antifungal antibiotic.
  • Biological description

    Heat shock protein 90 inhibitor and antifungal antibiotic. Binds to the N-terminal ATP/ADP-binding domain suppressing cell transformation induced by src, ras and mos. Induces cell cycle arrest at G1-S phase. Shows antiangiogenic effects in vivo.
  • Purity

    > 99%
  • CAS Number

    12772-57-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1aR,2Z,4E,14R,15aR)-8-Chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione
  • Molecular weight

    364.80
  • Molecular formula

    C18H17ClO6
  • PubChem identifier

    6323491
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1CC2C(O2)C=CC=CC(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1
  • Source

    Humicola fuscoatra

  • Research areas

References

This product has been referenced in:

  • He Y  et al. Radicicol, a heat shock protein 90 inhibitor, inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes. Biochem Biophys Res Commun 436:169-74 (2013). Read more (PubMed: 23727383) »
  • Roe SM  et al. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J Med Chem 42:260-6 (1999). Read more (PubMed: 9925731) »
  • Schulte TW  et al. Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. Mol Endocrinol 13:1435-48 (1999). Read more (PubMed: 10478836) »
  • Oikawa T  et al. Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis. Eur J Pharmacol 241:221-7 (1993). Read more (PubMed: 7694864) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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