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Is there something like AGE alone (without the BSA) that one could try? In the past, pure AGEs were used and it does not have any effect on the production of proinflammatory cytokines. It works when it is bound to BSA. BSA alone does not have any effect on cytokine production. Is it possible that we can discuss this over the phone ?
Asked on Sep 19 2011
Thank you for your phone call. I'd be happy to issue you either a credit or refund. Alternatively, a free of charge replacement with another antibody can be sent. I have checked our catalog for other potential suitable RAGE antibodies to be used in neutralization/receptor inhibition. As I am not certain where in the extracellular domain (residues 23 – 342) the AGE binding site would be, I have selected all RAGE antibodies with immunogen in the extracellular domain: ab37647 (https://www.abcam.com/RAGE-antibody-ab37647.html) ab7764 (https://www.abcam.com/RAGE-antibody-ab7764.html) ab78022 (https://www.abcam.com/RAGE-antibody-DD-A11-or-mAbA11-ab78022.html) ab86767 (https://www.abcam.com/RAGE-antibody-ab86767.html) ab87305 (https://www.abcam.com/RAGE-antibody-Azide-free-ab87305.html) None of these antibodies was tested in neutralization and would therefore qualify for our testing discount program. For UNTESTED species and/or applications, we have established a testing discount program. Here is a brief description of how it works: The testing discount program is for customers who like to use an antibody/protein on an untested species/application. You would purchase the antibody at full price, test it and submit an Abreview with your data (positive or negative). On your next order you will receive a discount for ONE antibody at the full price (100%) of the antibody you have tested. The terms and conditions applicable to this offer can be found here: www.abcam.com/collaborationdiscount. Please let me know how you would like to proceed and I'd be happy to arrange it for you. I look forward to hear back from you.
Answered on Sep 19 2011