• Product name
    Anti-RAIDD antibody [EPR1640Y]
    See all RAIDD primary antibodies
  • Description
    Rabbit monoclonal [EPR1640Y] to RAIDD
  • Host species
  • Tested applications
    Suitable for: WB, IP, ICC, Flow Cyt, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human RAIDD (C terminal). The exact sequence is proprietary.

  • Positive control
    • HeLa cell lysate and Human heart muscle tissue.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.


    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab52621 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 23 kDa (predicted molecular weight: 23 kDa).
IP 1/30.
ICC 1/100 - 1/250.
Flow Cyt 1/20.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.


  • Function
    Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.
  • Tissue specificity
    Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.
  • Sequence similarities
    Contains 1 CARD domain.
    Contains 1 death domain.
  • Domain
    Contains a death domain involved in the binding of RIP protein.
    The CARD domain mediates the interaction with caspase-2.
  • Information by UniProt
  • Database links
  • Alternative names
    • CASP2 and RIPK1 domain containing adaptor with death domain antibody
    • Caspase and RIP adapter with death domain antibody
    • Caspase and RIP adaptor with death domain antibody
    • Cradd antibody
    • CRADD_HUMAN antibody
    • Death adaptor molecule RAIDD antibody
    • Death domain containing protein CRADD antibody
    • Death domain-containing protein CRADD antibody
    • MGC9163 antibody
    • RIP associated ICH1/CED3 homologous protein with death domain antibody
    • RIP associated protein with a death domain antibody
    • RIP-associated protein with a death domain antibody
    see all


  • Anti-RAIDD antibody [EPR1640Y] (ab52621) at 1/1000 dilution + HeLa cell lysate at 10 µg

    goat anti-rabbit HRP at 1/2000 dilution

    Predicted band size: 23 kDa
    Observed band size: 23 kDa

  • ab52621, at a 1/50 dilution, staining Human RAIDD in heart muscle, using Immunohistochemistry, Paraffin embedded tissue.


This product has been referenced in:
  • Cruz VH  et al. Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction. Mol Metab 16:139-149 (2018). Read more (PubMed: 29935921) »
  • Di Donato N  et al. Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant. Am J Hum Genet 99:1117-1129 (2016). Read more (PubMed: 27773430) »
See all 4 Publications for this product

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