Overview

  • Product name

    Raloxifene hydrochloride, estrogen receptor modulator (SERM)
  • Description

    Selective estrogen receptor modulator (SERM)
  • Biological description

    Selective estrogen receptor modulator (SERM). Binds to both ERα (Kd = 90pM) and ERβ. Tissue-dependently inhibits or activates ER-induced transcription. Inhibits estradiol-induced progesterone receptor activity in hypothalamic cells (IC50 = 1nM). Orally Active.
  • Purity

    > 98%
  • CAS Number

    82640-04-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone hydrochloride
  • Molecular weight

    510.05
  • Molecular formula

    C28H27NO4S.HCl
  • PubChem identifier

    54900
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Muchmore DB Raloxifene: A selective estrogen receptor modulator (SERM) with multiple target system effects. Oncologist 5:388-92 (2000). Read more (PubMed: 11040275) »
  • Fitzpatrick SL  et al. Effect of estrogen agonists and antagonists on induction of progesterone receptor in a rat hypothalamic cell line. Endocrinology 140:3928-37 (1999). Read more (PubMed: 10465261) »
  • Kuiper GG  et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139:4252-63 (1998). Read more (PubMed: 9751507) »
  • Bryant HU  et al. An estrogen receptor basis for raloxifene action in bone. J Steroid Biochem Mol Biol 69:37-44 (0). Read more (PubMed: 10418979) »

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