Overview

  • Product name

    Raltitrexed, thymidylate synthase inhibitor
  • Description

    Potent antimetabolite antineoplastic agent. Selective thymidylate synthase inhibitor.
  • Biological description

    Potent antimetabolite antineoplastic agent. Selective thymidylate synthase inhibitor. Inhibits cell growth (IC50 = 9 nM, L1210 cells). Folic acid (ab143621) analog. Inhibits DNA and RNA synthesis. Shows antitumor effects in vivo.
  • Purity

    > 99%
  • CAS Number

    112887-68-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S)-2-[[5-[Methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic acid
  • Molecular weight

    458.49
  • Molecular formula

    C21H22N4O6S
  • PubChem identifier

    104758
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 10 mM and in DMSO to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=NC(=O)C2=C(N1)C=CC(=C2)CN(C)C3=CC=C(S3)C(=O)NC(CCC(=O)O)C(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Yu Y  et al. Intestinal absorption of raltitrexed and evaluation of the effects of absorption enhancers. Pharmazie 68:732-43 (2013). Read more (PubMed: 24147341) »
  • Favoni RE  et al. Preclinical studies identify novel targeted pharmacological strategies for treatment of human malignant pleural mesothelioma. Br J Pharmacol 166:532-53 (2012). Read more (PubMed: 22289125) »
  • Jarmula A Antifolate inhibitors of thymidylate synthase as anticancer drugs. Mini Rev Med Chem 10:1211-22 (2010). Read more (PubMed: 20854257) »
See 1 Publication for this product

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