Overview

  • Product name

    Ramosetron, 5-HT3 receptor antagonist
  • Description

    Highly potent, selective 5-HT3 receptor antagonist
  • Biological description

    Highly potent, selective 5-HT3 receptor antagonist (Ki values are 91 and 220 pM at human and rat receptors respectively). Shows antiemetic and anti-diarrhoeal effects in vivo. Orally active. Partially blood-brain barrier permeable.
  • Purity

    > 98%
  • CAS Number

    132036-88-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Hirata T  et al. Inhibitory effect of ramosetron on corticotropin releasing factor- and soybean oil-induced delays in gastric emptying in rats. J Gastroenterol Hepatol 27:1505-11 (2012). Read more (PubMed: 22554268) »
  • Hirata T  et al. Evaluation of the pharmacological profile of ramosetron, a novel therapeutic agent for irritable bowel syndrome. J Pharmacol Sci 104:263-73 (2007). Read more (PubMed: 17652911) »
  • Yamamoto C  et al. Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier. J Pharm Pharmacol 54:1055-63 (2002). Read more (PubMed: 12195819) »

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