Anti-RanBP3 antibody (ab235303)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-RanBP3 antibody
See all RanBP3 primary antibodies -
Description
Rabbit polyclonal to RanBP3 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to Human RanBP3 aa 1-250.
Database link: Q9H6Z4 -
Positive control
- IHC-P: Human testis and pancreatic cancer tissues.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab235303 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | 1/20 - 1/200. |
Target
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Function
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. -
Tissue specificity
Widely expressed with high levels in testis and heart. -
Sequence similarities
Contains 1 RanBD1 domain. -
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localization
Cytoplasm. Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 8498 Human
- Omim: 603327 Human
- SwissProt: Q9H6Z4 Human
- Unigene: 531752 Human
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Alternative names
- DKFZp586I1520 antibody
- Ran binding protein 3 antibody
- Ran-binding protein 3 antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RanBP3 antibody (ab235303)Paraffin-embedded human testis tissue stained for RanBP3 using ab235303 at 1/100 dilution in immunohistochemical analysis.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RanBP3 antibody (ab235303)Paraffin-embedded human pancreatic cancer tissue stained for RanBP3 using ab235303 at 1/100 dilution in immunohistochemical analysis.
Datasheets and documents
References
ab235303 has not yet been referenced specifically in any publications.
